What causes COPD Flare-ups? Home › Private: Ask the Pharmacist › Chronic Lower Respiratory Diseases Medication Questions › What causes COPD Flare-ups? Tagged: Chronic Lower Respiratory Diseases, Jay Harold, MedlinePlus This topic has 0 replies, 1 voice, and was last updated 8 years, 5 months ago by Jay Fulce. Viewing 1 post (of 1 total) Author Posts May 22, 2016 at 1:39 pm #2830 Jay FulceKeymaster Certain illnesses, colds, and lung infections from viruses or bacteria can lead to flare-ups. Other causes may include: Being around smoke or other pollutants Weather changes Doing too much activity Being run-down Feeling stressed or anxious From MedlinePlus Author Posts Viewing 1 post (of 1 total) You must be logged in to reply to this topic. Log In Username: Password: Keep me signed in Log In