Treatment of sleep disorder might help improve blood pressure control in this high-risk group

African-Americans with moderate or severe sleep apnea are twice as likely to have hard-to-control high blood pressure when their sleep apnea goes untreated, according to a new study funded mainly by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health. The findings, which researchers say may partially explain why African-Americans suffer hypertension at rates higher than any other group, point to screening and treatment of sleep apnea as another important strategy for keeping uncontrolled high blood pressure at bay.

A common disorder that blocks the upper airways and causes people to stop breathing during sleep, sleep apnea already has been linked to an increased risk of high blood pressure in whites, but the association in blacks has been largely understudied. This new research demonstrates this link in a large population of African-Americans. The results are scheduled to be published Dec. 10 in Circulation, a journal of the American Heart Association.

“This is an example of how NHLBI funded research is making important advances to our basic understanding of cardiovascular risk and sleep health,” said Michael Twery, Ph.D., director of the National Center on Sleep Disorders Research at NHLBI. “This report underscores the need for studies to determine whether screening groups at high risk for sleep apnea, such as African-Americans, would facilitate early medical intervention and reduce the risk or severity of heart disease.”

“This study identifies a risk factor for hard-to-control hypertension that until now has gone underrecognized in African-Americans,” said study leader Dayna Johnson, Ph.D., an assistant professor in the Department of Epidemiology at Rollins School of Public Health at Emory University in Atlanta. Johnson added that the disproportionately high rate of uncontrolled hypertension among African-Americans makes the study results even more consequential. A recent NIH-funded study showed that about 75 percent of African-American men and women are likely to develop high blood pressure by age 55, compared to 55 percent of white men and 40 percent of white women of the same age.

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Johnson noted that the current findings could provide more of an impetus for African-Americans with the condition to get evaluated for sleep apnea, which also appears to affect them more than it does whites. An estimated 1 in 4 African-Americans in the United States have moderate or severe sleep apnea, but most have not been diagnosed or treated by a doctor, according to a 2018 study led by Johnson when she worked at Brigham and Women’s Hospital in Boston.

In the new study, the researchers followed 664 African-Americans with hypertension who were participants in the Jackson Heart Study, the largest investigation of causes of cardiovascular disease in African-Americans. The researchers tested the participants for obstructive sleep apnea (the most common kind) with a special device used overnight in the home. Researchers classified sleep apnea as unaffected, mild, moderate, or severe based on the number of times a person either partially or completely stopped breathing during sleep. The tests revealed that more than a quarter of the participants had moderate or severe sleep apnea and that the condition had gone undiagnosed in almost all of them—i.e., 94 percent of the cases.  The remaining participants had either no sleep apnea, or a milder form of it.

The researchers also took blood pressure measurements and found that 48 percent of the participants had “uncontrolled” high blood pressure, meaning they had the condition even though they took one or two antihypertensive medications. About 14 percent had “resistant” hypertension, meaning they had the condition while on three or more antihypertensive medications. “Resistant” hypertension is more severe than “uncontrolled” and carries a higher risk for heart disease and death, the researchers said.

Moderate or severe sleep apnea & Hypertension

The researchers then compared measures of sleep apnea to categories of blood pressure control. Study participants with moderate or severe sleep apnea were twice as likely to have resistant hypertension when compared to participants without sleep apnea.  Those with severe sleep apnea were 3.5 times as likely to have resistant hypertension compared to participants without sleep apnea. Somewhat unexpectedly, the researchers found no association between milder forms of sleep apnea and uncontrolled or resistant hypertension.

The results suggest that African-Americans with more severe forms of sleep apnea are at higher risk of having hard-to-treat hypertension, the researchers said. The current study did not explore what proportion of resistant hypertension is attributable to sleep apnea.

Limitations of the Study

The study did not examine the mechanisms by which sleep apnea increases blood pressure. But Susan Redline, M.D., senior physician at Brigham and Women’s Hospital and the study’s senior author, said that earlier studies indicate that untreated sleep apnea can cause blood pressure to surge during sleep and remain high during the day when a patient is awake. Her earlier research showed that treatment of sleep apnea with continuous positive air pressure (CPAP) lowers blood pressure, especially during the night. CPAP and other breathing devices deliver slight air pressure through a mask and are highly effective for treatment of sleep apnea.

The study was supported by grants from the NHLBI (R01HL110068, 3R01HL110068-03S2; T32HL007901-18, and K01HL138211). Additional NHLBI support included the following: KL2TR001874, R01HL117323, and 5R35HL135818.   Other NIH support included funding from the National Institute of General Medical Sciences (U54GM115428) through the University of Mississippi Medical Center.  The Jackson Heart Study is supported and conducted in collaboration with Jackson State University (HHSN268201300049C and HHSN268201300050C), Tougaloo College (HHSN268201300048C), and the University of Mississippi Medical Center (HHSN268201300046C and HHSN268201300047C) contracts NHLBI and the National Institute for Minority Health and Health Disparities. The study was also supported by additional institutions outside of NIH, including the American Heart Association. For a more complete funding disclosure, please see the full research article.

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